Heart Rate And Qt Interval In Streptozotocin-induced Diabetic Rat
by Mr. Chris Howarth |
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Prolonged QT interval is a common finding in diabetic patients. The effects of streptozotocin (STZ) induced diabetes on QT interval has been investigated by application of 4 standard QT correction algorithms. The electrocardiogram was recorded in STZ-treated (60 mg/kg bodyweight, ip) and age-matched control rats with a biotelemetry system for the period of the study. Heart rate (HR) was significantly (P < 0.01) reduced and QT interval was signifycantly (P < 0.05) prolonged in diabetic rats compared to controls at 8, 10 and 12 weeks after STZ treatment. |
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